Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC3045823 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Lee Seongsoo S Liu Hsin-Ping HP Lin Wei-Yong WY Guo Huifu H Lu Bingwei B
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101201 50
Mutations in leucine-rich repeat kinase 2 (LRRK2) are linked to familial as well as sporadic forms of Parkinson's disease (PD), a neurodegenerative disease characterized by dysfunction and degeneration of dopaminergic and other types of neurons. The molecular and cellular mechanisms underlying LRRK2 action remain poorly defined. Here, we show that LRRK2 controls synaptic morphogenesis at the Drosophila neuromuscular junction. Loss of Drosophila LRRK2 results in synaptic overgrowth, whereas overe ...[more]