Ontology highlight
ABSTRACT:
SUBMITTER: Pucci F
PROVIDER: S-EPMC4960636 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160317 6282
Tumor-derived extracellular vesicles (tEVs) are important signals in tumor-host cell communication, yet it remains unclear how endogenously produced tEVs affect the host in different areas of the body. We combined imaging and genetic analysis to track melanoma-derived vesicles at organismal, cellular, and molecular scales to show that endogenous tEVs efficiently disseminate via lymphatics and preferentially bind subcapsular sinus (SCS) CD169(+) macrophages in tumor-draining lymph nodes (tdLNs) i ...[more]