Ontology highlight
ABSTRACT:
SUBMITTER: Dharaneeswaran H
PROVIDER: S-EPMC4961050 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Dharaneeswaran Harita H Abid Md Ruhul MR Yuan Lei L Dupuis Dylan D Beeler David D Spokes Katherine C KC Janes Lauren L Sciuto Tracey T Kang Peter M PM Jaminet Shou-Ching S SS Dvorak Ann A Grant Marianne A MA Regan Erzsébet Ravasz ER Aird William C WC
Circulation research 20140529 2
<h4>Rationale</h4>Forkhead box-O transcription factors (FoxOs) transduce a wide range of extracellular signals, resulting in changes in cell survival, cell cycle progression, and several cell type-specific responses. FoxO1 is expressed in many cell types, including endothelial cells (ECs). Previous studies have shown that Foxo1 knockout in mice results in embryonic lethality at E11 because of impaired vascular development. In contrast, somatic deletion of Foxo1 is associated with hyperproliferat ...[more]