Ontology highlight
ABSTRACT:
SUBMITTER: Yu W
PROVIDER: S-EPMC6400400 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
PLoS genetics 20190221 2
Heart valve disease is a major clinical problem worldwide. Cardiac valve development and homeostasis need to be precisely controlled. Hippo signaling is essential for organ development and tissue homeostasis, while its role in valve formation and morphology maintenance remains unknown. VGLL4 is a transcription cofactor in vertebrates and we found it was mainly expressed in valve interstitial cells at the post-EMT stage and was maintained till the adult stage. Tissue specific knockout of VGLL4 in ...[more]