Neuronal activity enhances tau propagation and tau pathology in vivo.
Ontology highlight
ABSTRACT:
SUBMITTER: Wu JW
PROVIDER: S-EPMC4961585 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Neuronal activity enhances tau propagation and tau pathology in vivo.
Wu Jessica W JW Hussaini S Abid SA Bastille Isle M IM Rodriguez Gustavo A GA Mrejeru Ana A Rilett Kelly K Sanders David W DW Cook Casey C Fu Hongjun H Boonen Rick A C M RA Herman Mathieu M Nahmani Eden E Emrani Sheina S Figueroa Y Helen YH Diamond Marc I MI Clelland Catherine L CL Wray Selina S Duff Karen E KE
Nature neuroscience 20160620 8
Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. Neuronal activity has been shown to regulate tau secretion, but its effect on tau pathol ...[more]
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