Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz FC
PROVIDER: S-EPMC6538342 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ortiz Fernando C FC Habermacher Chloé C Graciarena Mariana M Houry Pierre-Yves PY Nishiyama Akiko A Nait Oumesmar Brahim B Angulo María Cecilia MC
JCI insight 20190321
In demyelinating diseases such as Multiple Sclerosis (MS), demyelination of neuronal fibers impairs impulse conduction and causes axon degeneration. While neuronal activity stimulates oligodendrocyte production and myelination in normal conditions, it remains unclear whether the activity of demyelinated axons restores their loss-of-function in a harmful environment. To investigate this question, we established a model to induce a moderate optogenetic stimulation of demyelinated axons in the corp ...[more]