Ontology highlight
ABSTRACT:
SUBMITTER: Coetzee SG
PROVIDER: S-EPMC4962314 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Coetzee Simon G SG Pierce Steven S Brundin Patrik P Brundin Lena L Hazelett Dennis J DJ Coetzee Gerhard A GA
Scientific reports 20160727
Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrogates at r(2) ≥ 0.8) could alter cellular function, we assessed their location overlap with histone modification regions that indicate transcription regulation in 77 diverse cell types. We found statis ...[more]