Ontology highlight
ABSTRACT:
SUBMITTER: Schlingmann B
PROVIDER: S-EPMC4962485 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Schlingmann Barbara B Overgaard Christian E CE Molina Samuel A SA Lynn K Sabrina KS Mitchell Leslie A LA Dorsainvil White StevenClaude S Mattheyses Alexa L AL Guidot David M DM Capaldo Christopher T CT Koval Michael M
Nature communications 20160725
Claudins are tetraspan transmembrane tight-junction proteins that regulate epithelial barriers. In the distal airspaces of the lung, alveolar epithelial tight junctions are crucial to regulate airspace fluid. Chronic alcohol abuse weakens alveolar tight junctions, priming the lung for acute respiratory distress syndrome, a frequently lethal condition caused by airspace flooding. Here we demonstrate that in response to alcohol, increased claudin-5 paradoxically accompanies an increase in paracell ...[more]