Ontology highlight
ABSTRACT:
SUBMITTER: Rui YN
PROVIDER: S-EPMC7087352 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Rui Yan-Ning YN Chen Yawen Y Guo Yichen Y Bock Caroline E CE Hagan John P JP Kim Dong H DH Xu Zhen Z
Journal of cellular physiology 20191021 5
Podosomes and tight junctions (TJs) are subcellular compartments that both exist in endothelial cells and localize at cell surfaces. In contrast to the well-characterized role of TJs in maintaining cerebrovascular integrity, the specific function of endothelial podosomes remains unknown. Intriguingly, we discovered cross-talk between podosomes and TJs in human brain endothelial cells. Tight junction scaffold proteins ZO-1 and ZO-2 localize at podosomes in response to phorbol-12-myristate-13-acet ...[more]