Changing Azole Resistance: A Secondary Analysis of the MUTT I Randomized Clinical Trial.

ABSTRACT:

Importance

The development of multiple triazole resistance in pathogenic filamentous fungi has become an increasing clinical concern and has been shown to increase the risk for treatment failure.

Objective

To determine whether antifungal resistance increased during the Mycotic Ulcer Treatment Trial I (MUTT I), as measured by minimum inhibitory concentrations (MICs) in baseline cultures.

Design, setting, and participants

This secondary analysis of a double-masked, multicenter, randomized clinical trial included patients with culture- or smear-positive filamentous fungal corneal ulcer and a baseline visual acuity of 20/40 to 20/400. Culture-positive samples with susceptibility testing were included in this analysis. The patients were treated at multiple locations of the

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC4962688 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature