Ontology highlight
ABSTRACT:
SUBMITTER: Suter SR
PROVIDER: S-EPMC4962782 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Suter Scott R SR Sheu-Gruttadauria Jessica J Schirle Nicole T NT Valenzuela Rachel R Ball-Jones Alexi A AA Onizuka Kazumitsu K MacRae Ian J IJ Beal Peter A PA
Journal of the American Chemical Society 20160712 28
Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA structure necessitate chemical modification for drug development. Advances in the structural characterization of components of the human RNAi pathway have enabled structure-guided optimization of siRNA properties. Here we report the 2.3 Å resolution crystal structure of human Argonaute 2 (hAgo2), a key nuclease in the RNAi pathway, bound to ...[more]