Ontology highlight
ABSTRACT:
SUBMITTER: Panayiotou R
PROVIDER: S-EPMC4963197 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Panayiotou Richard R Miralles Francesc F Pawlowski Rafal R Diring Jessica J Flynn Helen R HR Skehel Mark M Treisman Richard R
eLife 20160615
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphoryla ...[more]