Ontology highlight
ABSTRACT:
SUBMITTER: Diamond MI
PROVIDER: S-EPMC4423694 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Diamond Marc I MI Cai Shirong S Boudreau Aaron A Carey Clifton J CJ Lyle Nicholas N Pappu Rohit V RV Swamidass S Joshua SJ Bissell Mina M Piwnica-Worms Helen H Shao Jieya J
The Journal of biological chemistry 20150213 14
The actin-binding protein profilin-1 (Pfn1) inhibits tumor growth and yet is also required for cell proliferation and survival, an apparent paradox. We previously identified Ser-137 of Pfn1 as a phosphorylation site within the poly-l-proline (PLP) binding pocket. Here we confirm that Ser-137 phosphorylation disrupts Pfn1 binding to its PLP-containing ligands with little effect on actin binding. We find in mouse xenografts of breast cancer cells that mimicking Ser-137 phosphorylation abolishes ce ...[more]