Ontology highlight
ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC4963198 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zheng Xinde X Boyer Leah L Jin Mingji M Mertens Jerome J Kim Yongsung Y Ma Li L Ma Li L Hamm Michael M Gage Fred H FH Hunter Tony T
eLife 20160610
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progenitor cells (NPC) to neuronal oxidative phosphorylation. The protein levels of c-MYC and N-MYC, transcriptional activators of the HK2 and LDHA genes, decrease dramatically. Constitutive expression of HK ...[more]