Ontology highlight
ABSTRACT:
SUBMITTER: Charles Richard JL
PROVIDER: S-EPMC4965029 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
PLoS genetics 20160728 7
FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair. Here, we present evidence that FACT could be directly involved in Base Excision Repair and elucidate the chromatin remodeling mechanisms of FACT during BER. We found that, upon oxidative stress, FACT is released from transcription related protein complexes to get associated with repair proteins and chromatin remodelers from the SWI/SNF ...[more]