Evaluating Prostate Cancer Using Fractional Tissue Composition of Radical Prostatectomy Specimens and Pre-Operative Diffusional Kurtosis Magnetic Resonance Imaging.

ABSTRACT: Evaluating tissue heterogeneity using non-invasive imaging could potentially improve prostate cancer assessment and treatment.20 patients with intermediate/high-risk prostate cancer underwent diffusion kurtosis imaging, including calculation of apparent diffusion (Dapp) and kurtosis (Kapp), prior to radical prostatectomy. Whole-mount tissue composition was quantified into: cellularity, luminal space, and fibromuscular stroma. Peripheral zone tumors were subdivided according to Gleason score.Peripheral zone tumors had increased cellularity (p<0.0001), decreased fibromuscular stroma (p<0.05) and decreased luminal space (p<0.0001). Gleason score ?4+3 tumors had significantly increased cellularity and decreased fibromuscular stroma compared to Gleason score ?3+4 (p<0.05). In tumors, there was a significant positive correlation between median Kapp and cellularity (? = 0.50; p<0.05), and a negative correlation with fibromuscular stroma (? = -0.45; p<0.05). In normal tissue, median Dapp had a significant positive correlation with luminal space (? = 0.65; p<0.05) and a negative correlation with cellularity (? = -0.49; p<0.05). Median Kapp and Dapp varied significantly between tumor and normal tissue (p<0.0001), but only median Kapp was significantly different between Gleason score ?4+3 and ?3+4 (p<0.05).Peripheral zone tumors have increased cellular heterogeneity which is reflected in mean Kapp, while normal prostate has a more homogeneous luminal space and cellularity better represented by Dapp.

SUBMITTER: Lawrence EM 

PROVIDER: S-EPMC4965080 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature