Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate.
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ABSTRACT:
SUBMITTER: Kersten KM
PROVIDER: S-EPMC4965881 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate.
Kersten Kortney M KM Matzger Adam J AJ
Chemical communications (Cambridge, England) 20160322 30
Structural and thermal data were obtained for a novel hemihydrate of 6-mercaptopurine. The hemihydrate shows increased solubility and bioavailability when compared to the monohydrate form, better stability against conversion in aqueous media than the anhydrate form, and a dehydration temperature of 240 °C, the highest of any known hydrate crystal. ...[more]
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