Ontology highlight
ABSTRACT:
SUBMITTER: Sabatino M
PROVIDER: S-EPMC4965906 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Sabatino Marianna M Hu Jinhui J Sommariva Michele M Gautam Sanjivan S Fellowes Vicki V Hocker James D JD Dougherty Sean S Qin Haiying H Klebanoff Christopher A CA Fry Terry J TJ Gress Ronald E RE Kochenderfer James N JN Stroncek David F DF Ji Yun Y Gattinoni Luca L
Blood 20160525 4
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures to generate relevant numbers of this T-cell population are undefined. Here, we provide a strategy for deriving large numbers of clinical-grade tumor-redirected TSCM starting from naive precursors. CD8(+)CD62L(+)CD45RA(+) naive T cells enriched by streptamer-based seri ...[more]