Ontology highlight
ABSTRACT:
SUBMITTER: Loboda A
PROVIDER: S-EPMC4967105 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Loboda Agnieszka A Damulewicz Milena M Pyza Elzbieta E Jozkowicz Alicja A Dulak Jozef J
Cellular and molecular life sciences : CMLS 20160421 17
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. The vertebrate Nrf2 belongs to Cap 'n' Collar (Cnc) bZIP family of transcription factors and shares a high homology with SKN-1 from Caenorhabditis elegans or CncC found in Drosophila melanogaster. The major ch ...[more]