Ontology highlight
ABSTRACT:
SUBMITTER: Barrett NA
PROVIDER: S-EPMC4967476 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Barrett Neil A NA Malouf Camille C Kapeni Chrysa C Bacon Wendi A WA Giotopoulos George G Jacobsen Sten Eirik W SEW Huntly Brian J BJ Ottersbach Katrin K
Cell reports 20160707 4
MLL-AF4+ infant B cell acute lymphoblastic leukemia is characterized by an early onset and dismal survival. It initiates before birth, and very little is known about the early stages of the disease's development. Using a conditional Mll-AF4-expressing mouse model in which fusion expression is targeted to the earliest definitive hematopoietic cells generated in the mouse embryo, we demonstrate that Mll-AF4 imparts enhanced B lymphoid potential and increases repopulation and self-renewal capacity ...[more]