Ontology highlight
ABSTRACT:
SUBMITTER: Kumar AR
PROVIDER: S-EPMC3011030 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Kumar Ashish R AR Yao Qing Q Li Quanzhi Q Sam Thien A TA Kersey John H JH
Leukemia research 20100925 3
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear. In the human leukemia cell lines - RS4;11 and SEMK2-M1, both of which express MLL-AF4 and AF4-MLL, we knocked down the expression of AF4-MLL using siRNA. Loss of AF4-MLL had no effect on ...[more]