Ontology highlight
ABSTRACT:
SUBMITTER: Root DH
PROVIDER: S-EPMC4967922 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Root David H DH Wang Hui-Ling HL Liu Bing B Barker David J DJ Mód László L Szocsics Péter P Silva Afonso C AC Maglóczky Zsófia Z Morales Marisela M
Scientific reports 20160801
The rodent ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) contain dopamine neurons intermixed with glutamate neurons (expressing vesicular glutamate transporter 2; VGluT2), which play roles in reward and aversion. However, identifying the neuronal compositions of the VTA and SNC in higher mammals has remained challenging. Here, we revealed VGluT2 neurons within the VTA and SNC of nonhuman primates and humans by simultaneous detection of VGluT2 mRNA and tyrosine hydroxylase ...[more]