Dataset Information

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmo Diet and Cancer cohort.

ABSTRACT:

Background

By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk.

Methods

We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants' dietary intake, assessed by a modified diet history method, was ranked according to a diet quality index that included six dietary components: saturated fat, polyunsaturated fat, fish, fiber, fruit and vegetables, and sucrose.

Results

The GRSLDL-C (P?=?5?×?10(-6)) and GRSHDL-C (P?=?0.02) but not GRSTG (P?=?0.08) were significantly associated with CVD risk. No significant interaction between the GRSs and diet quality was observed on CVD risk (P?>?0.39). A high compared to a low diet quality attenuated the association between GRSLDL-C and the risk of incident ischemic stroke (P interaction?=?0.01).

Conclusion

We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke.

SUBMITTER: Hellstrand S

PROVIDER: S-EPMC4968442 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort.

Hellstrand Sophie S Ericson Ulrika U Schulz Christina-Alexandra CA Drake Isabel I Gullberg Bo B Hedblad Bo B Engström Gunnar G Orho-Melander Marju M Sonestedt Emily E

Genes & nutrition 20160707

<h4>Background</h4>By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk.<h4>Methods</h4>We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 y ...[more]

PMID: 27551321

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