Ontology highlight
ABSTRACT:
SUBMITTER: Vannella KM
PROVIDER: S-EPMC4970463 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature immunology 20160404 5
Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment of type 2 inflammation in the lung in response to allergens or helminths. In contrast, AMCase-deficient mice showed a profound defect in type 2 immunity following infection with the chitin-containing ...[more]