Unknown

Dataset Information

0

The gut microbiome primes a cerebroprotective immune response after stroke.


ABSTRACT: Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome. Interestingly, the microbiome-mediated brain protection was absent in lymphocyte-deficient mice. These findings support the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.

SUBMITTER: Singh V 

PROVIDER: S-EPMC6092773 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

The gut microbiome primes a cerebroprotective immune response after stroke.

Singh Vikramjeet V   Sadler Rebecca R   Heindl Steffanie S   Llovera Gemma G   Roth Stefan S   Benakis Corinne C   Liesz Arthur A  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180530 8


Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome  ...[more]

Similar Datasets

| S-EPMC4291500 | biostudies-other
| S-EPMC9650036 | biostudies-literature
| S-EPMC10823282 | biostudies-literature
| S-SCDT-10_15252-EMMM_202217241 | biostudies-other
| S-EPMC4409480 | biostudies-literature
| S-EPMC8938272 | biostudies-literature
2024-08-27 | GSE273780 | GEO
| S-EPMC4970463 | biostudies-literature
| S-EPMC8315907 | biostudies-literature
| S-EPMC5081128 | biostudies-other