Ontology highlight
ABSTRACT:
SUBMITTER: Zhu H
PROVIDER: S-EPMC4970508 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Zhu Hui H Peck Spencer C SC Bonnot Florence F van der Donk Wilfred A WA Klinman Judith P JP
Journal of the American Chemical Society 20150812 33
Nonheme iron oxygenases that carry out four-electron oxidations of substrate have been proposed to employ iron(III) superoxide species to initiate this reaction [Paria, S.; Que, L.; Paine, T. K. Angew. Chem. Int. Ed. 2011, 50, 11129]. Here we report experimental evidence in support of this proposal. (18)O KIEs were measured for two recently discovered mononuclear nonheme iron oxygenases: hydroxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS). Competitive (18)O KIEs meas ...[more]