Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko M
PROVIDER: S-EPMC4971459 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kaneko Masayuki M Iwase Ikuko I Yamasaki Yuki Y Takai Tomoko T Wu Yan Y Kanemoto Soshi S Matsuhisa Koji K Asada Rie R Okuma Yasunobu Y Watanabe Takeshi T Imaizumi Kazunori K Nomura Yausyuki Y
Scientific reports 20160803
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a mechanism by which unfolded proteins that accumulate in the ER are transported to the cytosol for ubiquitin-proteasome-mediated degradation. Ubiquitin ligases (E3s) are a group of enzymes responsible for substrate selectivity and ubiquitin chain formation. The purpose of this study was to identify novel E3s involved in ERAD. Thirty-seven candidate genes were selected by searches for proteins with RING-finger motifs and transmembrane r ...[more]