Ontology highlight
ABSTRACT:
SUBMITTER: Fenech EJ
PROVIDER: S-EPMC7332293 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Fenech Emma J EJ Lari Federica F Charles Philip D PD Fischer Roman R Laétitia-Thézénas Marie M Bagola Katrin K Paton Adrienne W AW Paton James C JC Gyrd-Hansen Mads M Kessler Benedikt M BM Christianson John C JC
eLife 20200702
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E3s are predicted to be ER-localised, but for most their organisation and cellular roles remain poorly defined. Using a comparative proteomic workflow, we mapped over 450 protein-protein interactions for 21 stably expressed, full-length E3s. Bioinform ...[more]