An Atypical Tropomyosin in Drosophila with Intermediate Filament-like Properties.
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ABSTRACT:
SUBMITTER: Cho A
PROVIDER: S-EPMC4971881 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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An Atypical Tropomyosin in Drosophila with Intermediate Filament-like Properties.
Cho Aeri A Kato Masato M Whitwam Tess T Kim Ji Hoon JH Montell Denise J DJ
Cell reports 20160707 4
A longstanding mystery has been the absence of cytoplasmic intermediate filaments (IFs) from Drosophila despite their importance in other organisms. In the course of characterizing the in vivo expression and functions of Drosophila Tropomyosin (Tm) isoforms, we discovered an essential but unusual product of the Tm1 locus, Tm1-I/C, which resembles an IF protein in some respects. Like IFs, Tm1-I/C spontaneously forms filaments in vitro that are intermediate in diameter between F-actin and microtub ...[more]
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