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Palladium Catalysis Enables Benzylation of ?,?-Difluoroketone Enolates.

ABSTRACT: A palladium-catalyzed decarboxylative benzylation reaction of ?,?-difluoroketone enolates is reported, in which the key C(?)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to ?-benzyl-?,?-difluoroketone-based products, and should be useful for accessing biological probes.

SUBMITTER: Yang MH

PROVIDER: S-EPMC4972046 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.

Yang Ming-Hsiu MH Hunt Jordan R JR Sharifi Niusha N Altman Ryan A RA

Angewandte Chemie (International ed. in English) 20160617 31

A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes. ...[more]

PMID: 27312868

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