Ontology highlight
ABSTRACT:
SUBMITTER: Naylor CE
PROVIDER: S-EPMC4972137 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Naylor Claire E CE Bagnéris Claire C DeCaen Paul G PG Sula Altin A Scaglione Antonella A Clapham David E DE Wallace B A BA
The EMBO journal 20160212 8
Voltage-gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials. This paper describes the ion permeability characteristics and the crystal structure of a prokaryotic sodium channel, showing for the first time the detailed locations of sodium ions in the selectivity filter of a sodium channel. Electrostatic calculations ba ...[more]