Ontology highlight
ABSTRACT:
SUBMITTER: Thomaston JL
PROVIDER: S-EPMC4972211 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20160517 8
The M2 protein is a small proton channel found in the influenza A virus that is necessary for viral replication. The M2 channel is the target of a class of drugs called the adamantanes, which block the channel pore and prevent the virus from replicating. In recent decades mutations have arisen in M2 that prevent the adamantanes from binding to the channel pore, with the most prevalent of these mutations being S31N. Here we report the first crystal structure of the S31N mutant crystallized using ...[more]