Ontology highlight
ABSTRACT:
SUBMITTER: Bujak R
PROVIDER: S-EPMC4972307 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Bujak Renata R Mateo Jesús J Blanco Isabel I Izquierdo-García José Luis JL Dudzik Danuta D Markuszewski Michał J MJ Peinado Victor Ivo VI Laclaustra Martín M Barberá Joan Albert JA Barbas Coral C Ruiz-Cabello Jesús J
PloS one 20160803 8
Diagnosis of pulmonary arterial hypertension (PAH) is difficult due to the lack of specific clinical symptoms and biomarkers, especially at early stages. We compared plasma metabolic fingerprints of PAH patients (n = 20) with matched healthy volunteers (n = 20) using, for the first time, untargeted multiplatform metabolomics approach consisting of high-performance liquid and gas chromatography coupled with mass spectrometry. Multivariate statistical analyses were performed to select metabolites ...[more]