Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels.
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ABSTRACT:
SUBMITTER: Skaalure SC
PROVIDER: S-EPMC4972608 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels.
Skaalure Stacey C SC Akalp Umut U Vernerey Franck J FJ Bryant Stephanie J SJ
Advanced healthcare materials 20160119 4
Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics. ...[more]
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