Ontology highlight
ABSTRACT:
SUBMITTER: Molleston JM
PROVIDER: S-EPMC4973295 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Molleston Jerome M JM Sabin Leah R LR Moy Ryan H RH Menghani Sanjay V SV Rausch Keiko K Gordesky-Gold Beth B Hopkins Kaycie C KC Zhou Rui R Jensen Torben Heick TH Wilusz Jeremy E JE Cherry Sara S
Genes & development 20160701 14
RNA degradation is tightly regulated to selectively target aberrant RNAs, including viral RNA, but this regulation is incompletely understood. Through RNAi screening in Drosophila cells, we identified the 3'-to-5' RNA exosome and two components of the exosome cofactor TRAMP (Trf4/5-Air1/2-Mtr4 polyadenylation) complex, dMtr4 and dZcchc7, as antiviral against a panel of RNA viruses. We extended our studies to human orthologs and found that the exosome as well as TRAMP components hMTR4 and hZCCHC7 ...[more]