Ontology highlight
ABSTRACT:
SUBMITTER: Gupta AK
PROVIDER: S-EPMC6277966 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20181129 Pt 12
The crystal structure of Mycobacterium tuberculosis high-temperature requirement A (HtrA) protein was determined at 1.83 Å resolution. This membrane-associated protease is essential for the survival of M. tuberculosis. The crystal structure reveals that interactions between the PDZ domain and the catalytic domain in HtrA lead to an inactive conformation. This finding is consistent with its proposed role as a regulatory protease that is conditionally activated upon appropriate environmental trigg ...[more]