Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC4973363 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Chen Jinling J Xu Tianhua T Zhu Dandan D Wang Jianxin J Huang Caiqun C Lyu Lei L Hu Bin B Sun Wei W Duan Yinong Y
Cell death & disease 20160728 7
Liver fibrosis is a serious disease that is characterized by the excess deposition of extracellular matrix (ECM) components. Activated hepatic stellate cells (HSCs) are a major source of ECM and serve as a key regulator in liver fibrogenesis. Inactivation of HSCs is essential for liver fibrotic regression. The present study explores the underlying mechanisms of Schistosoma japonicum egg antigen p40 (Sjp40) promoting senescence in HSCs and antifibrosis. For the first time we report that Sjp40 inh ...[more]