Ontology highlight
ABSTRACT:
SUBMITTER: Deane RJ
PROVIDER: S-EPMC4973574 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Future medicinal chemistry 20120501 7
The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in inflammatory disorders, tumor outgrowth, diabetic complications and Alzheimer's disease (AD). RAGE transports circulating amyloid-β toxins across the blood-brain barrier (BBB) into the brain. RAGE-amyloid-β toxin interaction at the BBB leads to oxidative stress, inflammatory responses and reduced cerebral blood flow. Thus, regulating RAGE activity at the BBB and/or within brain could be beneficial to AD ...[more]