Ontology highlight
ABSTRACT:
SUBMITTER: Lanfranco MF
PROVIDER: S-EPMC7503657 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200901 17
Apolipoprotein E (<i>APOE</i>) is the major cholesterol carrier in the brain, affecting various normal cellular processes including neuronal growth, repair and remodeling of membranes, synaptogenesis, clearance and degradation of amyloid β (Aβ) and neuroinflammation. In humans, the <i>APOE</i> gene has three common allelic variants, termed E2, E3, and E4. <i>APOE4</i> is considered the strongest genetic risk factor for Alzheimer's disease (AD), whereas <i>APOE2</i> is neuroprotective. To perform ...[more]