Dataset Information

Lipid suppression via double inversion recovery with symmetric frequency sweep for robust 2D-GRAPPA-accelerated MRSI of the brain at 7?T.

ABSTRACT: This work presents a new approach for high-resolution MRSI of the brain at 7?T in clinically feasible measurement times. Two major problems of MRSI are the long scan times for large matrix sizes and the possible spectral contamination by the transcranial lipid signal. We propose a combination of free induction decay (FID)-MRSI with a short acquisition delay and acceleration via in-plane two-dimensional generalised autocalibrating partially parallel acquisition (2D-GRAPPA) with adiabatic double inversion recovery (IR)-based lipid suppression to allow robust high-resolution MRSI. We performed Bloch simulations to evaluate the magnetisation pathways of lipids and metabolites, and compared the results with phantom measurements. Acceleration factors in the range 2-25 were tested in a phantom. Five volunteers were scanned to verify the value of our MRSI method in vivo. GRAPPA artefacts that cause fold-in of transcranial lipids were suppressed via double IR, with a non-selective symmetric frequency sweep. The use of long, low-power inversion pulses (100?ms) reduced specific absorption rate requirements. The symmetric frequency sweep over both pulses provided good lipid suppression (>90%), in addition to a reduced loss in metabolite signal-to-noise ratio (SNR), compared with conventional IR suppression (52-70%). The metabolic mapping over the whole brain slice was not limited to a rectangular region of interest. 2D-GRAPPA provided acceleration up to a factor of nine for in vivo FID-MRSI without a substantial increase in g-factors (<1.1). A 64 × 64 matrix can be acquired with a common repetition time of ~1.3?s in only 8?min without lipid artefacts caused by acceleration. Overall, we present a fast and robust MRSI method, using combined double IR fat suppression and 2D-GRAPPA acceleration, which may be used in (pre)clinical studies of the brain at 7?T.

SUBMITTER: Hangel G

PROVIDER: S-EPMC4973691 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Lipid suppression via double inversion recovery with symmetric frequency sweep for robust 2D-GRAPPA-accelerated MRSI of the brain at 7 T.

Hangel Gilbert G Strasser Bernhard B Považan Michal M Gruber Stephan S Chmelík Marek M Gajdošík Martin M Trattnig Siegfried S Bogner Wolfgang W

NMR in biomedicine 20150915 11

This work presents a new approach for high-resolution MRSI of the brain at 7 T in clinically feasible measurement times. Two major problems of MRSI are the long scan times for large matrix sizes and the possible spectral contamination by the transcranial lipid signal. We propose a combination of free induction decay (FID)-MRSI with a short acquisition delay and acceleration via in-plane two-dimensional generalised autocalibrating partially parallel acquisition (2D-GRAPPA) with adiabatic double i ...[more]

PMID: 26370781

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Project description:PURPOSE:Proton MR spectroscopic imaging (MRSI) benefits from B0 ? 7T and multichannel receive coils, promising substantial resolution improvements. However, MRSI acquisition with high spatial resolution requires efficient acceleration and coil combination. To speed up the already-fast sampling via concentric rings, we implemented additional, non-Cartesian, hybrid through-time/through-k-space (tt/tk)-generalized autocalibrating partially parallel acquisition (GRAPPA). A new multipurpose interleaved calibration scan (interleaved MUSICAL) acquires reference data for both coil combination and PI. This renders the reconstruction process (especially PI) less sensitive to instabilities. METHODS:Six healthy volunteers were scanned at 7T. Three calibration datasets for coil combination and PI were recorded: a) iMUSICAL, b) static MUSICAL as prescan, c) moved MUSICAL as prescan with misaligned head position. The coil combination performance, including motion sensitivity, of iMUSICAL was compared to MUSICAL for single-slice free induction decay (FID)-MRSI. Through-time/through-k-space-GRAPPA with constant/variable-density undersampling was evaluated on the same data, comparing the three calibration datasets. Additionally, the proposed method was successfully applied to 3D whole-brain FID-MRSI. RESULTS:Using iMUSICAL for coil combination yielded the highest signal-to-noise ratio (SNR) (+9%) and lowest Cramer-Rao lower bounds (CRLBs) (-6%) compared to both MUSICAL approaches, with similar metabolic map quality. Also, excellent mean g-factors of 1.07 and low residual lipid aliasing were obtained when using iMUSICAL as calibration data for two-fold, variable-density undersampling, while significantly degraded metabolic maps were obtained using the misaligned MUSICAL calibration data. CONCLUSION:Through-time/through-k-space-GRAPPA can accelerate already time-efficient non-Cartesian spatial-spectral 2D/3D-MRSI encoding even further. Particularly promising results have been achieved using iMUSICAL as a robust, interleaved multipurpose calibration for MRSI reconstruction, without extra calibration prescan.

Dataset Information

Lipid suppression via double inversion recovery with symmetric frequency sweep for robust 2D-GRAPPA-accelerated MRSI of the brain at 7?T.

Publications

Lipid suppression via double inversion recovery with symmetric frequency sweep for robust 2D-GRAPPA-accelerated MRSI of the brain at 7 T.

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