Ontology highlight
ABSTRACT:
SUBMITTER: Azzi J
PROVIDER: S-EPMC4973867 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cell reports 20160428 6
Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in ...[more]