Ontology highlight
ABSTRACT:
SUBMITTER: Schudel A
PROVIDER: S-EPMC7305972 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature nanotechnology 20200610 6
Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering cargo to specific cells in the lymph node cortex and paracortex is difficult. Here, we describe a delivery system to overcome lymphatic and intra-lymph node transport barriers by combining nanoparticles that are rapidly conveyed to draining lymph node ...[more]