FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
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ABSTRACT:
SUBMITTER: Michl J
PROVIDER: S-EPMC4973888 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
Michl Johanna J Zimmer Jutta J Buffa Francesca M FM McDermott Ultan U Tarsounas Madalena M
Nature structural & molecular biology 20160620 8
The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability. Our results identify a new role of FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, thereby affecting cell survival and treatment responses. ...[more]
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2017-06-02 | PXD006106 | Pride