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FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

ABSTRACT: The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability. Our results identify a new role of FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, thereby affecting cell survival and treatment responses.

SUBMITTER: Michl J 

PROVIDER: S-EPMC4973888 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

Michl Johanna J   Zimmer Jutta J   Buffa Francesca M FM   McDermott Ultan U   Tarsounas Madalena M  

Nature structural & molecular biology 20160620 8

The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability. Our results identify a new role of FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, thereby affecting cell survival and treatment responses. ...[more]

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