Ontology highlight
ABSTRACT:
SUBMITTER: Lachaud C
PROVIDER: S-EPMC4770513 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lachaud Christophe C Moreno Alberto A Marchesi Francesco F Toth Rachel R Blow J Julian JJ Rouse John J
Science (New York, N.Y.) 20160121 6275
Mono-ubiquitination of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs), but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair, but we show that recruitment of Fan1 by Ub-Fancd2 is dispensable for ICL repair. Instead, Fan1 recruitment--and activity--restrains DNA replication fork progression and prevents chromosome abnormal ...[more]