Dataset Information

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease.

ABSTRACT:

Background and aims

The substantial characteristics of Irritable Bowel Syndrome (IBS) are associated with estrogens in women. Both soy isoflavones and vitamin D can modulate estrogen receptors in the colonic smooth muscles. The aim of this study was to investigate the effects of soy isoflavones, vitamin D and their probable interactions in women with IBS.

Methods

In a factorial blinded randomized clinical trial, 100 women with IBS (age:18-75yr, were randomly assigned in 4 arms to receive either placebo of vitamin D and placebo of soy isoflavones (P+P), or placebo of vitamin D and soy isoflavones (P+S), or vitamin D and placebo of soy isoflavones (D+P), or vitamin D and soy isoflavones (D+S) for 6 weeks. Dosage of soy isoflavone was 2 capsules of 20 mg soy isoflavones per day, and dosage of vitamin D was one pearl of 50'000 IU biweekly. The clinical outcomes were IBS symptoms severity scores (IBS-SSS), disease- specific quality of life (IBS-QOL) and total score (IBS-TS) that evaluated at weeks 0, 6, and 10, and compared to each other.

Results

IBS-TS improved significantly in both S+P and D+P groups (p- value = 0.004, 0.015). The interaction effect of soy isoflavones and vitamin D on IBS-TS was significant (p<0.05). The interaction effect of soy isoflavones with vitamin D and the main effect of vitamin D on IBS-SSS were not statistically significant, whereas IBS-SSS decreased significantly in S+P and D+P groups (p-value = 0.001, 0.047 respectively).

Conclusion

Our results indicate that co-administration of soy isoflavones with vitamin D did not improve the IBS- SSS and IBS- QOL; however, it improved the IBS-TS.

Trial registration

Clinical Trials.gov NCT02026518.

SUBMITTER: Jalili M

PROVIDER: S-EPMC4973900 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease.

Jalili Mahsa M Hekmatdoost Azita A Vahedi Homayoon H Poustchi Hossein H Khademi Behnam B Saadi Mohsen M Zemestani Maryam M Janani Leila L

PloS one 20160804 8

<h4>Background and aims</h4>The substantial characteristics of Irritable Bowel Syndrome (IBS) are associated with estrogens in women. Both soy isoflavones and vitamin D can modulate estrogen receptors in the colonic smooth muscles. The aim of this study was to investigate the effects of soy isoflavones, vitamin D and their probable interactions in women with IBS.<h4>Methods</h4>In a factorial blinded randomized clinical trial, 100 women with IBS (age:18-75yr, were randomly assigned in 4 arms to ...[more]

PMID: 27490103

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Dataset Information

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease.

Background and aims

Methods

Results

Conclusion

Trial registration

Publications

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease.

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