Ontology highlight
ABSTRACT:
SUBMITTER: Montefiori L
PROVIDER: S-EPMC4975037 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cell reports 20160121 4
Early B cell development is characterized by large-scale Igh locus contraction prior to V(D)J recombination to facilitate a highly diverse Ig repertoire. However, an understanding of the molecular architecture that mediates locus contraction remains unclear. We have combined high-resolution chromosome conformation capture (3C) techniques with 3D DNA FISH to identify three conserved topological subdomains. Each of these topological folds encompasses a major VH gene family that become juxtaposed i ...[more]