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Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.

ABSTRACT: By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and ?-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.

SUBMITTER: Lin X

PROVIDER: S-EPMC4975647 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.

Lin Xi X Chen Jinsen J Shahsavari Shahien S Green Nathanael N Goyal Deepti D Fang Shiyue S

Organic letters 20160722 15

By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis. ...[more]

PMID: 27447361

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