Sublayer-Specific Coding Dynamics during Spatial Navigation and Learning in Hippocampal Area CA1.

ABSTRACT: The mammalian hippocampus is critical for spatial information processing and episodic memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics, morphology, connectivity, and electrophysiological properties. It is therefore possible that distinct CA1 PC subpopulations encode different features of the environment and differentially contribute to learning. To test this hypothesis, we optically monitored activity in deep and superficial CA1 PCs segregated along the radial axis of the mouse hippocampus and assessed the relationship between sublayer dynamics and learning. Superficial place maps were more stable than deep during head-fixed exploration. Deep maps, however, were preferentially stabilized during goal-oriented learning, and representation of the reward zone b

SUBMITTER: Danielson NB 

PROVIDER: S-EPMC4975984 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature