Ontology highlight
ABSTRACT:
SUBMITTER: Cao X
PROVIDER: S-EPMC4976014 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cao Xin X Cao Xin X Lu Ying Y Zhang Xianyu X Kovalovsky Damian D
Journal of immunology (Baltimore, Md. : 1950) 20160708 4
Expression of the transcription factor Zbtb1 is required for normal lymphoid development. We report in the present study that Zbtb1 maintains genome integrity in immune progenitors, without which cells undergo increased DNA damage and p53-mediated apoptosis during replication and differentiation. Increased DNA damage in Zbtb1-mutant (ScanT) progenitors was due to increased sensitivity to replication stress, which was a consequence of inefficient activation of the S-phase checkpoint response. Inc ...[more]