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ZBTB1 is a determinant of lymphoid development.

ABSTRACT: In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

SUBMITTER: Siggs OM

PROVIDER: S-EPMC3260866 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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ZBTB1 is a determinant of lymphoid development.

Siggs Owen M OM Li Xiaohong X Xia Yu Y Beutler Bruce B

The Journal of experimental medicine 20111226 1

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as ...[more]

PMID: 22201126

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